Numerical study on the effects of blood perfusion and tumor metabolism on tumor temperature for targeted hyperthermia considering a realistic geometrical model of head layers using the finite element method

Abstract The main aim of the present work is to determine temperature distribution in normal and cancerous tissues achieve desired condition hyperthermia. Hyperthermia can be defined as mild elevation 40–46 °C, which induces cancer cell death enhances effects radiotherapy chemotherapy. In research, realistic geometry human head layers tumor are modelled, geometrically, then simulated similar real samples MRI images with size 5990 mm 3 . healthy was obtained based on solution Penne’s bio-heat transfer equation utilizing Finite Element scheme. Employing accurate boundary conditions for thermal simulation problem, two brain, namely, white matter (WM) gray (GM), well cerebrospinal fluid (CSF) skull, considered analysis. order examine hyperthermia conditions, different blood perfusion rates metabolism analyzed. results showed that by reducing rate from 0.0016 0.0005(ml/(ml.s)), increased nearly 0.2 ℃ at center implying variations have not a significant influence its temperature. Moreover, it found when increases five times (equal 125 × 10 W/m ) than value 25,000 ), reaches range needed ablation brain (40–46 ℃). also indicated manipulation metabolic via could efficiently employed estimate amount heat tumor.